A case report of a prolonged decrease in tacrolimus clearance due to co-administration of nirmatrelvir/ritonavir in a lung transplant recipient receiving itraconazole prophylaxis

• Main Authors: Ayumi Tsuzawa (Author), Yoshiki Katada (Author), Keisuke Umemura (Author), Mitsuhiro Sugimoto (Author), Asami Nishikawa (Author), Yu-ki Sato (Author), Yuko Yoshida (Author), Noriaki Kitada (Author), Atsushi Yonezawa (Author), Daisuke Nakajima (Author), Hiroshi Date (Author), Tomohiro Terada (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Drug-drug interaction management is complex. Nirmatrelvir/ritonavir is a potent cytochrome P450 (CYP) 3A inhibitor and influences pharmacokinetics of co-administered drugs. Although there are several reports about drug-drug interactions of nirmatrelvir/ritonavir, an influence of...