A case report of a prolonged decrease in tacrolimus clearance due to co-administration of nirmatrelvir/ritonavir in a lung transplant recipient receiving itraconazole prophylaxis

• Váldodahkkit: Ayumi Tsuzawa (Dahkki), Yoshiki Katada (Dahkki), Keisuke Umemura (Dahkki), Mitsuhiro Sugimoto (Dahkki), Asami Nishikawa (Dahkki), Yu-ki Sato (Dahkki), Yuko Yoshida (Dahkki), Noriaki Kitada (Dahkki), Atsushi Yonezawa (Dahkki), Daisuke Nakajima (Dahkki), Hiroshi Date (Dahkki), Tomohiro Terada (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: BMC, 2023-04-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Abstract Background Drug-drug interaction management is complex. Nirmatrelvir/ritonavir is a potent cytochrome P450 (CYP) 3A inhibitor and influences pharmacokinetics of co-administered drugs. Although there are several reports about drug-drug interactions of nirmatrelvir/ritonavir, an influence of...