External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease

• मुख्य लेखकों: Christina Schräpel (लेखक), Lukas Kovar (लेखक), Dominik Selzer (लेखक), Ute Hofmann (लेखक), Florian Tran (लेखक), Walter Reinisch (लेखक), Matthias Schwab (लेखक), Thorsten Lehr (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Infliximab is approved for treatment of various chronic inflammatory diseases including inflammatory bowel disease (IBD). However, high variability in infliximab trough levels has been associated with diverse response rates. Model-informed precision dosing (MIPD) with population pharmacokinetic mode...