External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease

• Main Authors: Christina Schräpel (Author), Lukas Kovar (Author), Dominik Selzer (Author), Ute Hofmann (Author), Florian Tran (Author), Walter Reinisch (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infliximab is approved for treatment of various chronic inflammatory diseases including inflammatory bowel disease (IBD). However, high variability in infliximab trough levels has been associated with diverse response rates. Model-informed precision dosing (MIPD) with population pharmacokinetic mode...