Distinct anti-proliferative effects of herbal melanin on human acute monocytic leukemia THP-1 cells and embryonic kidney HEK293 cells

• Autores principales: Adila El-Obeid (Autor), Hala Alajmi (Autor), Mashael Harbi (Autor), Wesam Bin Yahya (Autor), Hamad Al-Eidi (Autor), Monira Alaujan (Autor), Adil Haseeb (Autor), Thadeo Trivilegio (Autor), Alshaimaa Alhallaj (Autor), Saleh Alghamdi (Autor), Abdul-Wali Ajlouni (Autor), Sabine Matou-Nasri (Autor)
• Formato: Libro
• Publicado: BMC, 2020-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Herbal melanin (HM) is a dark pigment extracted from the seed coat of Nigella sativa L. and known to exert biological effects via toll-like receptor 4 (TLR4). Recently, TLR4 was described as involved in natural programmed cell death (apoptosis). Tumor and embryonic cells are used...