Distinct anti-proliferative effects of herbal melanin on human acute monocytic leukemia THP-1 cells and embryonic kidney HEK293 cells

• Main Authors: Adila El-Obeid (Author), Hala Alajmi (Author), Mashael Harbi (Author), Wesam Bin Yahya (Author), Hamad Al-Eidi (Author), Monira Alaujan (Author), Adil Haseeb (Author), Thadeo Trivilegio (Author), Alshaimaa Alhallaj (Author), Saleh Alghamdi (Author), Abdul-Wali Ajlouni (Author), Sabine Matou-Nasri (Author)
• Format: Book
• Published: BMC, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Herbal melanin (HM) is a dark pigment extracted from the seed coat of Nigella sativa L. and known to exert biological effects via toll-like receptor 4 (TLR4). Recently, TLR4 was described as involved in natural programmed cell death (apoptosis). Tumor and embryonic cells are used...