Novel Inhibitor of Keap1-Nrf2 Protein-Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo

• Hlavní autoři: Zhihao Chen (Autor), Hongyuan Yao (Autor), Alessandra Marie Encarnacion (Autor), Jujin Jeong (Autor), Yunju Choi (Autor), Sangwook Park (Autor), Sunwoo Lee (Autor), Taehoon Lee (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2024-07-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Keap1 interacts with Nrf2 by assisting in its ubiquitination and subsequent proteolysis. By preventing ROS accumulation during RANKL-induced osteoclastogenesis, Nrf2 activation can prevent the differentiation of osteoclasts. Additionally, inhibiting the Keap1-Nrf2 PPI can be an effective strategy fo...