Novel Inhibitor of Keap1-Nrf2 Protein-Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo

• Príomhchruthaitheoirí: Zhihao Chen (Údar), Hongyuan Yao (Údar), Alessandra Marie Encarnacion (Údar), Jujin Jeong (Údar), Yunju Choi (Údar), Sangwook Park (Údar), Sunwoo Lee (Údar), Taehoon Lee (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2024-07-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Keap1 interacts with Nrf2 by assisting in its ubiquitination and subsequent proteolysis. By preventing ROS accumulation during RANKL-induced osteoclastogenesis, Nrf2 activation can prevent the differentiation of osteoclasts. Additionally, inhibiting the Keap1-Nrf2 PPI can be an effective strategy fo...