Structural optimization and de novo design of dengue virus entry inhibitory peptides.

• Main Authors: Joshua M Costin (Author), Ekachai Jenwitheesuk (Author), Shee-Mei Lok (Author), Elizabeth Hunsperger (Author), Kelly A Conrads (Author), Krystal A Fontaine (Author), Craig R Rees (Author), Michael G Rossmann (Author), Sharon Isern (Author), Ram Samudrala (Author), Scott F Michael (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resolution structural data from a pre-entry dimeric form o...