Structural optimization and de novo design of dengue virus entry inhibitory peptides.

• المؤلفون الرئيسيون: Joshua M Costin (مؤلف), Ekachai Jenwitheesuk (مؤلف), Shee-Mei Lok (مؤلف), Elizabeth Hunsperger (مؤلف), Kelly A Conrads (مؤلف), Krystal A Fontaine (مؤلف), Craig R Rees (مؤلف), Michael G Rossmann (مؤلف), Sharon Isern (مؤلف), Ram Samudrala (مؤلف), Scott F Michael (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2010-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resolution structural data from a pre-entry dimeric form o...