Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms

• Auteurs principaux: Haifeng Eishingdrelo (Auteur), Xiaofa Qin (Auteur), Luwa Yuan (Auteur), Sathapana Kongsamut (Auteur), Lei Yu (Auteur)
• Format: Livre
• Publié: Elsevier, 2022-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse proteins to form signaling networks. Multiple 14-3-3 isoforms exist...