Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms

• Main Authors: Haifeng Eishingdrelo (Author), Xiaofa Qin (Author), Luwa Yuan (Author), Sathapana Kongsamut (Author), Lei Yu (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse proteins to form signaling networks. Multiple 14-3-3 isoforms exist...