Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

• Главные авторы: Binbin Cui (Автор), Xiying Hou (Автор), Mengjun Liu (Автор), Qing Li (Автор), Chao Yu (Автор), Shenglei Zhang (Автор), Yi Wang (Автор), Jun Wang (Автор), Shougang Zhuang (Автор), Feng Liu (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Предметы: article
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The histone methyltransferase SET and MYND domain protein 2 (SMYD2) has been implicated in tumorigenesis through methylating histone H3 at lysine36 (H3K36) and some non-histone substrates. Currently, the role of SMYD2 in acute kidney injury (AKI) remains unknown. Here, we investigated the effects of...