Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

• Main Authors: Binbin Cui (Author), Xiying Hou (Author), Mengjun Liu (Author), Qing Li (Author), Chao Yu (Author), Shenglei Zhang (Author), Yi Wang (Author), Jun Wang (Author), Shougang Zhuang (Author), Feng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The histone methyltransferase SET and MYND domain protein 2 (SMYD2) has been implicated in tumorigenesis through methylating histone H3 at lysine36 (H3K36) and some non-histone substrates. Currently, the role of SMYD2 in acute kidney injury (AKI) remains unknown. Here, we investigated the effects of...