Tat-functionalized Ag-Fe3O4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery

• Main Authors: Ergang Liu (Author), Meng Zhang (Author), Hui Cui (Author), Junbo Gong (Author), Yongzhuo Huang (Author), Jianxin Wang (Author), Yanna Cui (Author), Weibing Dong (Author), Lu Sun (Author), Huining He (Author), Victor C. Yang (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide (Tat), producing Tat-modified Ag-Fe3O4 nanocomposites (Tat-FeAgNPs). To load drugs, an -SH containing linker, 3-merc...