Surgical menopause enhances hippocampal amyloidogenesis following global cerebral ischemia

• Main Authors: Erin L. Scott (Author), Quan-Guang Zhang (Author), Yan Dong (Author), Dong Han (Author), Rui-Min Wang (Author), Ratna K. Vadlamudi (Author), Darrell W. Brann (Author)
• Format: Book
• Published: Elsevier, 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Prematurely menopausal women have a doubled lifetime risk of dementia and a 5-fold increased risk of mortality from neurological disorders, but the molecular mechanisms underlying these risks remain unclear. We hypothesized that ischemia-induced amyloidogenesis may be enhanced in the hip...