Surgical menopause enhances hippocampal amyloidogenesis following global cerebral ischemia

• Autors principals: Erin L. Scott (Autor), Quan-Guang Zhang (Autor), Yan Dong (Autor), Dong Han (Autor), Rui-Min Wang (Autor), Ratna K. Vadlamudi (Autor), Darrell W. Brann (Autor)
• Format: Llibre
• Publicat: Elsevier, 2014-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Background: Prematurely menopausal women have a doubled lifetime risk of dementia and a 5-fold increased risk of mortality from neurological disorders, but the molecular mechanisms underlying these risks remain unclear. We hypothesized that ischemia-induced amyloidogenesis may be enhanced in the hip...