Prediction of diacerein inhibition activity against interleukin-1 receptors through docking method and tracing of pharmacokinetic profiles and their toxicity

• Main Authors: Frengki Frengki (Author), Vivi Sofia (Author), Deddi Prima Putra (Author), Fatma Sri Wahyuni (Author), Daan Khambri (Author), Henni Vanda (Author)
• Format: Book
• Published: Universitas Ahmad Dahlan, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-1 is one of the cytokines involved in joint diseases such as osteoarthritis. IL-1 plays a role in maintaining the balance of proteolytic proteins:MMPs and TIMPs inhibitors. Increased expression and uncontrolled IL-1 activity tend to increase the role of MMPs in degrading proteoglycans and joint t...