Prediction of diacerein inhibition activity against interleukin-1 receptors through docking method and tracing of pharmacokinetic profiles and their toxicity

• Glavni autori: Frengki Frengki (Autor), Vivi Sofia (Autor), Deddi Prima Putra (Autor), Fatma Sri Wahyuni (Autor), Daan Khambri (Autor), Henni Vanda (Autor)
• Format: Knjiga
• Izdano: Universitas Ahmad Dahlan, 2020-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

IL-1 is one of the cytokines involved in joint diseases such as osteoarthritis. IL-1 plays a role in maintaining the balance of proteolytic proteins:MMPs and TIMPs inhibitors. Increased expression and uncontrolled IL-1 activity tend to increase the role of MMPs in degrading proteoglycans and joint t...