Osteopontin is a key player for local adipose tissue macrophage proliferation in obesity

• Main Authors: Matteo Tardelli (Author), Karina Zeyda (Author), Veronica Moreno-Viedma (Author), Bettina Wanko (Author), Nicole G. Grün (Author), Günther Staffler (Author), Maximilian Zeyda (Author), Thomas M. Stulnig (Author)
• Format: Book
• Published: Elsevier, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recent findings point towards an important role of local macrophage proliferation also in obesity-induced adipose tissue inflammation that underlies insulin resistance and type 2 diabetes. Osteopontin (OPN) is an inflammatory cytokine highly upregulated in adipose tissue (AT) of obese and...