An Investigational Study on the Role of <i>CYP2D6</i>, <i>CYP3A4</i> and <i>UGT</i>s Genetic Variation on Fesoterodine Pharmacokinetics in Young Healthy Volunteers

<b><i>Introduction:</i></b> Fesoterodine is one of the most widely used antimuscarinic drugs to treat an overactive bladder. Fesoterodine is extensively hydrolyzed by esterases to 5-hydroxymethyl tolterodine (5-HMT), the major active metabolite. CYP2D6 and CYP3A4 mainly metab...

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Main Authors: Andrea Rodríguez-Lopez (Author), Dolores Ochoa (Author), Paula Soria-Chacartegui (Author), Samuel Martín-Vilchez (Author), Marcos Navares-Gómez (Author), Eva González-Iglesias (Author), Sergio Luquero-Bueno (Author), Manuel Román (Author), Gina Mejía-Abril (Author), Francisco Abad-Santos (Author)
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Publicado em: MDPI AG, 2024-09-01T00:00:00Z.
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