An Investigational Study on the Role of <i>CYP2D6</i>, <i>CYP3A4</i> and <i>UGT</i>s Genetic Variation on Fesoterodine Pharmacokinetics in Young Healthy Volunteers

• 主要な著者: Andrea Rodríguez-Lopez (著者), Dolores Ochoa (著者), Paula Soria-Chacartegui (著者), Samuel Martín-Vilchez (著者), Marcos Navares-Gómez (著者), Eva González-Iglesias (著者), Sergio Luquero-Bueno (著者), Manuel Román (著者), Gina Mejía-Abril (著者), Francisco Abad-Santos (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

<b><i>Introduction:</i></b> Fesoterodine is one of the most widely used antimuscarinic drugs to treat an overactive bladder. Fesoterodine is extensively hydrolyzed by esterases to 5-hydroxymethyl tolterodine (5-HMT), the major active metabolite. CYP2D6 and CYP3A4 mainly metab...