Genetic analysis of Wnt/PCP genes in neural tube defects

• Автори: Zhongzhong Chen (Автор), Yunping Lei (Автор), Xuanye Cao (Автор), Yufang Zheng (Автор), Fang Wang (Автор), Yihua Bao (Автор), Rui Peng (Автор), Richard H. Finnell (Автор), Ting Zhang (Автор), Hongyan Wang (Автор)
• Формат: Книга
• Опубліковано: BMC, 2018-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube closure (NTC). Knockout mice that are heterozygotes of single PCP genes li...