Genetic analysis of Wnt/PCP genes in neural tube defects

• Main Authors: Zhongzhong Chen (Author), Yunping Lei (Author), Xuanye Cao (Author), Yufang Zheng (Author), Fang Wang (Author), Yihua Bao (Author), Rui Peng (Author), Richard H. Finnell (Author), Ting Zhang (Author), Hongyan Wang (Author)
• Format: Book
• Published: BMC, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube closure (NTC). Knockout mice that are heterozygotes of single PCP genes li...