Screening of Novel Antimicrobial Diastereomers of Azithromycin-Thiosemicarbazone Conjugates: A Combined LC-SPE/Cryo NMR, MS/MS and Molecular Modeling Approach

• Main Authors: Iva Habinovec (Author), Ivana Mikulandra (Author), Paula Pranjić (Author), Saša Kazazić (Author), Hana Čipčić Paljetak (Author), Antun Barišić (Author), Branimir Bertoša (Author), Mirjana Bukvić (Author), Predrag Novak (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A well-known class of antibacterials, 14- and 15-membered macrolides are widely prescribed to treat upper and lower respiratory tract infections. Azithromycin is a 15-membered macrolide antibiotic possessing a broad spectrum of antibacterial potency and favorable pharmacokinetics. Bacterial resistan...