Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling

• Main Authors: Matthijs W. van Hoogdalem (Author), Ryota Tanaka (Author), Khaled Abduljalil (Author), Trevor N. Johnson (Author), Scott L. Wexelblatt (Author), Henry T. Akinbi (Author), Alexander A. Vinks (Author), Tomoyuki Mizuno (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To allow the conceptualization of fetal buprenorphine e...