Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling

• المؤلفون الرئيسيون: Matthijs W. van Hoogdalem (مؤلف), Ryota Tanaka (مؤلف), Khaled Abduljalil (مؤلف), Trevor N. Johnson (مؤلف), Scott L. Wexelblatt (مؤلف), Henry T. Akinbi (مؤلف), Alexander A. Vinks (مؤلف), Tomoyuki Mizuno (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2024-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To allow the conceptualization of fetal buprenorphine e...