Isatin improves oligoasthenospermia caused by busulfan by regulating GSH/GPX4 axis to inhibit ferroptosis

• Main Authors: Chengniu Wang (Author), Weizhen Wang (Author), Jin Dong (Author), Xiaoran Li (Author), Taowen Ye (Author), Fanshuo Zeng (Author), Mingyu Jiang (Author), Jianwu Shi (Author), Xiaorong Wang (Author), Lei Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionFerroptosis, induced by iron overload and an imbalance in redox homeostasis, promotes the generation of reactive oxygen species (ROS), leading to iron-dependent lipid peroxides (LPO) and oxidative stress. Lipid peroxidation induced by reactive oxygen species is essential for the progress...