Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.

• Glavni autori: Nicholas J Tobias (Autor), Torsten Seemann (Autor), Sacha J Pidot (Autor), Jessica L Porter (Autor), Laurent Marsollier (Autor), Estelle Marion (Autor), Franck Letournel (Autor), Tasnim Zakir (Autor), Joseph Azuolas (Autor), John R Wallace (Autor), Hui Hong (Autor), John K Davies (Autor), Benjamin P Howden (Autor), Paul D R Johnson (Autor), Grant A Jenkin (Autor), Timothy P Stinear (Autor)
• Format: Knjiga
• Izdano: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS) locus spans a 120 kb region of a 174 kb mega...