Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.

• Main Authors: Nicholas J Tobias (Author), Torsten Seemann (Author), Sacha J Pidot (Author), Jessica L Porter (Author), Laurent Marsollier (Author), Estelle Marion (Author), Franck Letournel (Author), Tasnim Zakir (Author), Joseph Azuolas (Author), John R Wallace (Author), Hui Hong (Author), John K Davies (Author), Benjamin P Howden (Author), Paul D R Johnson (Author), Grant A Jenkin (Author), Timothy P Stinear (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS) locus spans a 120 kb region of a 174 kb mega...