Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Autophagy and Mitophagy Thereby Restoring Osteoblast Function In Vitro and In Vivo

• मुख्य लेखकों: Liang Chen (लेखक), Xiang Shi (लेखक), She-Ji Weng (लेखक), Jun Xie (लेखक), Jia-Hao Tang (लेखक), De-Yi Yan (लेखक), Bing-Zhang Wang (लेखक), Zhong-Jie Xie (लेखक), Zong-Yi Wu (लेखक), Lei Yang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Chronic long-term glucocorticoids (GC) use is associated with glucocorticoid-induced osteoporosis (GIOP) by inhibiting the survival and impairing the functions of osteoblasts. Autophagy and mitophagy play key roles in osteoblast differentiation, mineralization and survival, and mounting evidence hav...