Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Autophagy and Mitophagy Thereby Restoring Osteoblast Function In Vitro and In Vivo

• Main Authors: Liang Chen (Author), Xiang Shi (Author), She-Ji Weng (Author), Jun Xie (Author), Jia-Hao Tang (Author), De-Yi Yan (Author), Bing-Zhang Wang (Author), Zhong-Jie Xie (Author), Zong-Yi Wu (Author), Lei Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic long-term glucocorticoids (GC) use is associated with glucocorticoid-induced osteoporosis (GIOP) by inhibiting the survival and impairing the functions of osteoblasts. Autophagy and mitophagy play key roles in osteoblast differentiation, mineralization and survival, and mounting evidence hav...