Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

• প্রধান লেখক: Yikai Zhang (লেখক), Ling Xu (লেখক), Shaohua Chen (লেখক), Xianfeng Zha (লেখক), Wei Wei (লেখক), Yangqiu Li (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2019-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells. However, it remains unclear which antigen is specifically recognized by the TCR Vβ21 T cell c...