Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

Abstract We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells. However, it remains unclear which antigen is specifically recognized by the TCR Vβ21 T cell c...

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Main Authors: Yikai Zhang (Author), Ling Xu (Author), Shaohua Chen (Author), Xianfeng Zha (Author), Wei Wei (Author), Yangqiu Li (Author)
Format: Book
Published: BMC, 2019-06-01T00:00:00Z.
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