Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

• Autores principales: Yikai Zhang (Autor), Ling Xu (Autor), Shaohua Chen (Autor), Xianfeng Zha (Autor), Wei Wei (Autor), Yangqiu Li (Autor)
• Formato: Libro
• Publicado: BMC, 2019-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells. However, it remains unclear which antigen is specifically recognized by the TCR Vβ21 T cell c...