Single‐dose of LC51‐0255, a selective S1P1 receptor modulator, showed dose‐dependent and reversible reduction of absolute lymphocyte count in humans

Abstract Reducing the peripheral absolute lymphocyte count (ALC) is a promising therapeutic approach in treating autoimmune diseases. LC51‐0255 is a sphingosine‐1‐phosphate 1 receptor modulator, which is known to decrease the peripheral ALC. We aimed to assess the pharmacokinetics (PKs), pharmacodyn...

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Main Authors: Sang Won Lee (Author), Inyoung Hwang (Author), Jaeseong Oh (Author), SeungHwan Lee (Author), In‐Jin Jang (Author), Kyung‐Sang Yu (Author)
Format: Book
Published: Wiley, 2022-04-01T00:00:00Z.
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