Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa

• Váldodahkkit: Siham A. Alissa (Dahkki), Hanan A. Alghulikah (Dahkki), Zeid A. Alothman (Dahkki), Sameh M. Osman (Dahkki), Sonia Del Prete (Dahkki), Clemente Capasso (Dahkki), Alessio Nocentini (Dahkki), Claudiu T. Supuran (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (bacteria, fungi, and protozoa) was shown to p...