Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

• Main Authors: Özge Başer (Author), Yavuz Yavuz (Author), Deniz Öykü Özen (Author), Hüseyin Buğra Özgün (Author), Sami Ağuş (Author), Cihan Civan Civaş (Author), Deniz Atasoy (Author), Bayram Yılmaz (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a vital role in induction of satiety. Chronic consumption of high-fat diet is known to reduce hypothalamic neuronal sensitivity to hormone...