Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

• Main Authors: Hannes Gierke (Author), Susan Mouchantat (Author), Sabine Berg (Author), Michael Grimm (Author), Stefan Hadlich (Author), Marie-Luise Kromrey (Author), Thomas Nolte (Author), Teresa Pfrommer (Author), Vincent Rönnpagel (Author), Adrian Rump (Author), Kerstin Schaefer (Author), Ann-Cathrin Willmann (Author), Werner Weitschies (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral administration. These agglomerates, referring to descr...