Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

• Prif Awduron: Hannes Gierke (Awdur), Susan Mouchantat (Awdur), Sabine Berg (Awdur), Michael Grimm (Awdur), Stefan Hadlich (Awdur), Marie-Luise Kromrey (Awdur), Thomas Nolte (Awdur), Teresa Pfrommer (Awdur), Vincent Rönnpagel (Awdur), Adrian Rump (Awdur), Kerstin Schaefer (Awdur), Ann-Cathrin Willmann (Awdur), Werner Weitschies (Awdur)
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• Cyhoeddwyd: MDPI AG, 2023-03-01T00:00:00Z.
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Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral administration. These agglomerates, referring to descr...