Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

• Váldodahkkit: Hannes Gierke (Dahkki), Susan Mouchantat (Dahkki), Sabine Berg (Dahkki), Michael Grimm (Dahkki), Stefan Hadlich (Dahkki), Marie-Luise Kromrey (Dahkki), Thomas Nolte (Dahkki), Teresa Pfrommer (Dahkki), Vincent Rönnpagel (Dahkki), Adrian Rump (Dahkki), Kerstin Schaefer (Dahkki), Ann-Cathrin Willmann (Dahkki), Werner Weitschies (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2023-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral administration. These agglomerates, referring to descr...