Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia

• Main Authors: Yi Xu (Author), Christopher Hino (Author), David J. Baylink (Author), Jeffrey Xiao (Author), Mark E. Reeves (Author), Jiang F. Zhong (Author), Saied Mirshahidi (Author), Huynh Cao (Author)
• Format: Book
• Published: BMC, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Acute myeloid leukemia (AML) has the lowest survival rate among the leukemias. Targeting intracellular metabolism and energy production in leukemic cells can be a promising therapeutic strategy for AML. Recently, we presented the successful use of vitamin D (1,25VD3) gene therapy to treat A...