Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia

• Главные авторы: Yi Xu (Автор), Christopher Hino (Автор), David J. Baylink (Автор), Jeffrey Xiao (Автор), Mark E. Reeves (Автор), Jiang F. Zhong (Автор), Saied Mirshahidi (Автор), Huynh Cao (Автор)
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• Опубликовано: BMC, 2022-04-01T00:00:00Z.
• Предметы: article
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Abstract Acute myeloid leukemia (AML) has the lowest survival rate among the leukemias. Targeting intracellular metabolism and energy production in leukemic cells can be a promising therapeutic strategy for AML. Recently, we presented the successful use of vitamin D (1,25VD3) gene therapy to treat A...