Effect of ASP2205 fumarate, a novel 5-HT2C receptor agonist, on urethral closure function in rats

• Main Authors: Takao Ishigami (Author), Koji Ueshima (Author), Masashi Ukai (Author), Norio Asai (Author), Hajime Takamatsu (Author), Masanori Yokono (Author), Masahiro Takeda (Author), Noriyuki Masuda (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacological profile of ASP2205 fumarate (ASP2205), a novel 5-HT2C receptor agonist, was evaluated in vitro and in vivo. ASP2205 showed potent and selective agonistic activity for the human 5-HT2C receptor, with an EC50 of 0.85 nM in the intracellular Ca2+ mobilization assay. Rat 5-HT2C recep...