Effect of ASP2205 fumarate, a novel 5-HT2C receptor agonist, on urethral closure function in rats

• المؤلفون الرئيسيون: Takao Ishigami (مؤلف), Koji Ueshima (مؤلف), Masashi Ukai (مؤلف), Norio Asai (مؤلف), Hajime Takamatsu (مؤلف), Masanori Yokono (مؤلف), Masahiro Takeda (مؤلف), Noriyuki Masuda (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2019-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The pharmacological profile of ASP2205 fumarate (ASP2205), a novel 5-HT2C receptor agonist, was evaluated in vitro and in vivo. ASP2205 showed potent and selective agonistic activity for the human 5-HT2C receptor, with an EC50 of 0.85 nM in the intracellular Ca2+ mobilization assay. Rat 5-HT2C recep...