The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in <i>Staphylococcus aureus</i>

• Main Authors: Jan Balansky (Author), Kenneth Pfarr (Author), Christiane Szekat (Author), Stefan Kehraus (Author), Tilman Aden (Author), Miriam Grosse (Author), Rolf Jansen (Author), Thomas Hesterkamp (Author), Andrea Schiefer (Author), Gabriele M. König (Author), Marc Stadler (Author), Achim Hoerauf (Author), Gabriele Bierbaum (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in <i>S. aureus</i> using fluctuation analysis at 4 × minimum inh...