The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in <i>Staphylococcus aureus</i>

• Автори: Jan Balansky (Автор), Kenneth Pfarr (Автор), Christiane Szekat (Автор), Stefan Kehraus (Автор), Tilman Aden (Автор), Miriam Grosse (Автор), Rolf Jansen (Автор), Thomas Hesterkamp (Автор), Andrea Schiefer (Автор), Gabriele M. König (Автор), Marc Stadler (Автор), Achim Hoerauf (Автор), Gabriele Bierbaum (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in <i>S. aureus</i> using fluctuation analysis at 4 × minimum inh...