Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

• Glavni autori: Ke-Gang Linghu (Autor), Tian Zhang (Autor), Guang-Tao Zhang (Autor), Peng Lv (Autor), Wen-Jun Zhang (Autor), Guan-Ding Zhao (Autor), Shi-Hang Xiong (Autor), Qiu-Shuo Ma (Autor), Ming-Ming Zhao (Autor), Meiwan Chen (Autor), Yuan-Jia Hu (Autor), Chang-Sheng Zhang (Autor), Hua Yu (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2024-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by Kelch-like ECH-associated protein 1 (Keap1) alkylation plays a central role in anti-inflammatory therapy. However, activators of Nrf2 through alkylation of Keap1-Kelch domain have not been identified. Deoxynyboquinone (DNQ) is a nat...