Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

• Main Authors: Ke-Gang Linghu (Author), Tian Zhang (Author), Guang-Tao Zhang (Author), Peng Lv (Author), Wen-Jun Zhang (Author), Guan-Ding Zhao (Author), Shi-Hang Xiong (Author), Qiu-Shuo Ma (Author), Ming-Ming Zhao (Author), Meiwan Chen (Author), Yuan-Jia Hu (Author), Chang-Sheng Zhang (Author), Hua Yu (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by Kelch-like ECH-associated protein 1 (Keap1) alkylation plays a central role in anti-inflammatory therapy. However, activators of Nrf2 through alkylation of Keap1-Kelch domain have not been identified. Deoxynyboquinone (DNQ) is a nat...