In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1

• Prif Awduron: Alexey Goltsov (Awdur), Galina Lebedeva (Awdur), Ian Humphery-Smith (Awdur), Gregory Goltsov (Awdur), Oleg Demin (Awdur), Igor Goryanin (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2010-07-01T00:00:00Z.
• Pynciau: article
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The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective to PGHS-1/PGHS-2 and time dependent/independent...