In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1

• Main Authors: Alexey Goltsov (Author), Galina Lebedeva (Author), Ian Humphery-Smith (Author), Gregory Goltsov (Author), Oleg Demin (Author), Igor Goryanin (Author)
• Format: Book
• Published: MDPI AG, 2010-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective to PGHS-1/PGHS-2 and time dependent/independent...