Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers

• Main Authors: James O. McNamara (Author), Aloysius J. Klingelhutz (Author), Luiza I. Hernandez (Author), Frank J. Hernandez (Author), Katie S. Flenker (Author), Paloma H. Giangrande (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2013-03-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Recent clinical trials of small interfering RNAs (siRNAs) highlight the need for robust delivery technologies that will facilitate the successful application of these therapeutics to humans. Arguably, cell targeting by conjugation to cell-specific ligands provides a viable solution to this problem....