Interpreting protein variant effects with computational predictors and deep mutational scanning

• मुख्य लेखकों: Benjamin J. Livesey (लेखक), Joseph A. Marsh (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2022-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Computational predictors of genetic variant effect have advanced rapidly in recent years. These programs provide clinical and research laboratories with a rapid and scalable method to assess the likely impacts of novel variants. However, it can be difficult to know to what extent we can trust their...