Interpreting protein variant effects with computational predictors and deep mutational scanning

• Հիմնական հեղինակներ: Benjamin J. Livesey (Հեղինակ), Joseph A. Marsh (Հեղինակ)
• Ձևաչափ: Գիրք
• Հրապարակվել է: The Company of Biologists, 2022-06-01T00:00:00Z.
• Խորագրեր: article
• Առցանց հասանելիություն: Connect to this object online.

Computational predictors of genetic variant effect have advanced rapidly in recent years. These programs provide clinical and research laboratories with a rapid and scalable method to assess the likely impacts of novel variants. However, it can be difficult to know to what extent we can trust their...